CryoProt: A Protein Pretraining Framework with Cross-Box Interactions on Cryo-EM Density Maps

Despite the growing availability of cryo-electron microscopy (cryo-EM) density maps, effectively leveraging them for protein representation remains challenging. First, current methods lack a general-purpose protein pretraining framework tailored for cryo-EM density maps, designed for protein-related property prediction. Second, existing approaches typically partition density maps into local box regions and model them independently, overlooking interactions across boxes which are essential for capturing global structural context in cryo-EM density map. To address these challenges, we propose CryoProt, a protein pretraining framework designed for cryo-EM density maps. CryoProt introduces a Map Encoder based on multi-head latent attention (MLA), where box-level representations interact through a shared latent space, enabling explicit modeling of cross-box dependencies within the density map. Furthermore, we adopt a multi-task pretraining strategy to learn generalizable representations that can be effectively transferred to diverse downstream tasks, such as protein flexibility prediction, where cryo-EM density maps are not required and can be inferred implicitly by the pretrained model. Experimental results demonstrate that CryoProt consistently outperforms existing state-of-the-art methods across multiple benchmarks, achieving up to 12% improvement over the best-performing baselines, highlighting the importance of modeling cross-box interactions in cryo-EM data. The source code is publicly available at https://anonymous.4open.science/r/CryoProt.

PetroBench: A Benchmark for Large Language Models in Petroleum Engineering

Large Language Models are increasingly applied in the petroleum industry, highlighting the need for a domain-specific evaluation framework. This study develops a benchmark for LLMs in petroleum engineering, including a three-stage process of data preprocessing, quality filtering, and multi-model validation. Using expert review, a standardized question bank with strong domain relevance and discriminative capability was constructed. The benchmark covers production, reservoir, and drilling engineering, with 1,200 questions across multiple-choice, true or false, term definition, and short-answer formats. Eight mainstream LLMs were evaluated under a unified API environment. Results show that models performed better on subjective than objective questions, indicating weaknesses in factual knowledge discrimination. The highest accuracies for multiple-choice and true or false questions were 65.3% and 74.3%, respectively. Gemini-3-Pro, Kimi-K2.5, and Claude-Opus-4.6-Thinking achieved the best overall scores of 72%-74%. Models performed best in production engineering and weakest in reservoir engineering. Chinese models showed advantages in multiple-choice questions, while international models performed slightly better in short-answer questions. The benchmark provides a reproducible and practical reference for evaluating and deploying LLMs in petroleum engineering.

Learning a Kinodynamic Trajectory Manifold for Impact-Aware Compliant Catching of Fast-Moving Objects

Fast catching of free-flying objects is difficult because of short reaction time, impact uncertainty, and kinodynamic constraints. We use reinforcement learning in simulation to collect successful catching trajectories and learn a low-dimensional kinodynamic trajectory manifold. At run time, the estimated object initial state is mapped directly to a reference catching trajectory without online nonlinear optimization. The trajectory is tracked with compliant control near contact for improved impact absorption and capture stability.

Open-H-Embodiment: A Large-Scale Dataset for Enabling Foundation Models in Medical Robotics

Autonomous medical robots hold promise to improve patient outcomes, reduce provider workload, democratize access to care, and enable superhuman precision. However, autonomous medical robotics has been limited by a fundamental data problem: existing medical robotic datasets are small, single-embodiment, and rarely shared openly, restricting the development of foundation models that the field needs to advance. We introduce Open-H-Embodiment, the largest open dataset of medical robotic video with synchronized kinematics to date, spanning more than 49 institutions and multiple robotic platforms including the CMR Versius, Intuitive Surgical's da Vinci, da Vinci Research Kit (dVRK), Rob Surgical BiTrack, Virtual Incision's MIRA, Moon Surgical Maestro, and a variety of custom systems, spanning surgical manipulation, robotic ultrasound, and endoscopy procedures. We demonstrate the research enabled by this dataset through two foundation models. GR00T-H is the first open foundation vision-language-action model for medical robotics, which is the only evaluated model to achieve full end-to-end task completion on a structured suturing benchmark (25% of trials vs. 0% for all others) and achieves 64% average success across a 29-step ex vivo suturing sequence. We also train Cosmos-H-Surgical-Simulator, the first action-conditioned world model to enable multi-embodiment surgical simulation from a single checkpoint, spanning nine robotic platforms and supporting in silico policy evaluation and synthetic data generation for the medical domain. These results suggest that open, large-scale medical robot data collection can serve as critical infrastructure for the research community, enabling advances in robot learning, world modeling, and beyond.

Nexusformer: Nonlinear Attention Expansion for Stable and Inheritable Transformer Scaling

Scaling Transformers typically necessitates training larger models from scratch, as standard architectures struggle to expand without discarding learned representations. We identify the primary bottleneck in the attention mechanism's linear projections, which strictly confine feature extraction to fixed-dimensional subspaces, limiting both expressivity and incremental capacity. To address this, we introduce Nexusformer, which replaces linear $Q/K/V$ projections with a Nexus-Rank layer, a three-stage nonlinear mapping driven by dual activations in progressively higher dimensional spaces. This design overcomes the linearity constraint and enables lossless structured growth: new capacity can be injected along two axes via zero-initialized blocks that preserve pretrained knowledge. Experiments on language modeling and reasoning benchmarks demonstrate that Nexusformer matches Tokenformer's perplexity using up to 41.5\% less training compute during progressive scaling (240M to 440M). Furthermore, our analysis of growth dynamics reveals that zero initialization induces a stable convergence trajectory, allowing us to derive a geometric scaling law that accurately predicts performance across expansion scales.

How Creative Are Large Language Models in Generating Molecules?

Molecule generation requires satisfying multiple chemical and biological constraints while searching a large and structured chemical space. This makes it a non-binary problem, where effective models must identify non-obvious solutions under constraints while maintaining exploration to improve success by escaping local optima. From this perspective, creativity is a functional requirement in molecular generation rather than an aesthetic notion. Large language models (LLMs) can generate molecular representations directly from natural language prompts, but it remains unclear what type of creativity they exhibit in this setting and how it should be evaluated. In this work, we study the creative behavior of LLMs in molecular generation through a systematic empirical evaluation across physicochemical, ADMET, and biological activity tasks. We characterize creativity along two complementary dimensions, convergent creativity and divergent creativity, and analyze how different factors shape these behaviors. Our results indicate that LLMs exhibit distinct patterns of creative behavior in molecule generation, such as an increase in constraint satisfaction when additional constraints are imposed. Overall, our work is the first to reframe the abilities required for molecule generation as creativity, providing a systematic understanding of creativity in LLM-based molecular generation and clarifying the appropriate use of LLMs in molecular discovery pipelines.

ProUIE: A Macro-to-Micro Progressive Learning Method for LLM-based Universal Information Extraction

LLM-based universal information extraction (UIE) methods often rely on additional information beyond the original training data, which increases training complexity yet often yields limited gains. To address this, we propose ProUIE, a Macro-to-Micro progressive learning approach that improves UIE without introducing any external information. ProUIE consists of three stages: (i) macro-level Complete Modeling (CM), which learns NER, RE, and EE along their intrinsic difficulty order on the full training data to build a unified extraction foundation, (ii) meso-level Streamlined Alignment (SA), which operates on sampled data with simplified target formats, streamlining and regularizing structured outputs to make them more concise and controllable, and (iii) micro-level Deep Exploration (DE), which applies GRPO with stepwise fine-grained rewards (SFR) over structural units to guide exploration and improve performance. Experiments on 36 public datasets show that ProUIE consistently improves unified extraction, outperforming strong instruction-tuned baselines on average for NER and RE while using a smaller backbone, and it further demonstrates clear gains in large-scale production-oriented information extraction.

SRAM-Based Compute-in-Memory Accelerator for Linear-decay Spiking Neural Networks

Spiking Neural Networks (SNNs) have emerged as a biologically inspired alternative to conventional deep networks, offering event-driven and energy-efficient computation. However, their throughput remains constrained by the serial update of neuron membrane states. While many hardware accelerators and Compute-in-Memory (CIM) architectures efficiently parallelize the synaptic operation (W x I) achieving O(1) complexity for matrix-vector multiplication, the subsequent state update step still requires O(N) time to refresh all neuron membrane potentials. This mismatch makes state update the dominant latency and energy bottleneck in SNN inference. To address this challenge, we propose an SRAM-based CIM for SNN with Linear Decay Leaky Integrate-and-Fire (LD-LIF) Neuron that co-optimizes algorithm and hardware. At the algorithmic level, we replace the conventional exponential membrane decay with a linear decay approximation, converting costly multiplications into simple additions while accuracy drops only around 1%. At the architectural level, we introduce an in-memory parallel update scheme that performs in-place decay directly within the SRAM array, eliminating the need for global sequential updates. Evaluated on benchmark SNN workloads, the proposed method achieves a 1.1 x to 16.7 x reduction of SOP energy consumption, while providing 15.9 x to 69 x more energy efficiency, with negligible accuracy loss relative to original decay models. This work highlights that beyond accelerating the (W x I) computation, optimizing state-update dynamics within CIM architectures is essential for scalable, low-power, and real-time neuromorphic processing.

ProactiveMobile: A Comprehensive Benchmark for Boosting Proactive Intelligence on Mobile Devices

Multimodal large language models (MLLMs) have made significant progress in mobile agent development, yet their capabilities are predominantly confined to a reactive paradigm, where they merely execute explicit user commands. The emerging paradigm of proactive intelligence, where agents autonomously anticipate needs and initiate actions, represents the next frontier for mobile agents. However, its development is critically bottlenecked by the lack of benchmarks that can address real-world complexity and enable objective, executable evaluation. To overcome these challenges, we introduce ProactiveMobile, a comprehensive benchmark designed to systematically advance research in this domain. ProactiveMobile formalizes the proactive task as inferring latent user intent across four dimensions of on-device contextual signals and generating an executable function sequence from a comprehensive function pool of 63 APIs. The benchmark features over 3,660 instances of 14 scenarios that embrace real-world complexity through multi-answer annotations. To ensure quality, a team of 30 experts conducts a final audit of the benchmark, verifying factual accuracy, logical consistency, and action feasibility, and correcting any non-compliant entries. Extensive experiments demonstrate that our fine-tuned Qwen2.5-VL-7B-Instruct achieves a success rate of 19.15%, outperforming o1 (15.71%) and GPT-5 (7.39%). This result indicates that proactivity is a critical competency widely lacking in current MLLMs, yet it is learnable, emphasizing the importance of the proposed benchmark for proactivity evaluation.

Think Proprioceptively: Embodied Visual Reasoning for VLA Manipulation

Vision-language-action (VLA) models typically inject proprioception only as a late conditioning signal, which prevents robot state from shaping instruction understanding and from influencing which visual tokens are attended throughout the policy. We introduce ThinkProprio, which converts proprioception into a sequence of text tokens in the VLM embedding space and fuses them with the task instruction at the input. This early fusion lets embodied state participate in subsequent visual reasoning and token selection, biasing computation toward action-critical evidence while suppressing redundant visual tokens. In a systematic ablation over proprioception encoding, state entry point, and action-head conditioning, we find that text tokenization is more effective than learned projectors, and that retaining roughly 15% of visual tokens can match the performance of using the full token set. Across CALVIN, LIBERO, and real-world manipulation, ThinkProprio matches or improves over strong baselines while reducing end-to-end inference latency over 50%.